Limited Competition for the Continuation of Cure Glomerulonephropathy (CureGN) Participating Clinical Centers (U01 Clinical Trial Not Allowed) | RFA DK 22 512

Opportunity Information: Apply for RFA DK 22 512

This funding opportunity (RFA-DK-22-512) is a National Institutes of Health (NIH) cooperative agreement (U01) intended to continue the work of the Cure Glomerulonephropathy (CureGN) Network by providing ongoing support to its Participating Clinical Centers (PCCs). CureGN is a multicenter, observational cohort study focused on people with glomerular diseases, with the broader goal of improving clinical care and outcomes across these patient populations. Because the activity is observational and the notice of funding opportunity specifies "Clinical Trial Not Allowed," applicants are expected to conduct follow-up, data collection, and biospecimen activities within an observational research framework rather than testing interventions in a clinical trial setting.

The central purpose of the continuation is practical and operational: the PCCs will keep tracking and assessing participants who were already enrolled in CureGN and will also enroll a limited number of new participants. A major emphasis is placed on improving participant retention over time, since long-term follow-up is essential for understanding disease trajectories, treatment patterns in real-world care, and outcomes. Alongside retention, the PCCs are expected to refine and expand approaches for remote or virtual participation, which can reduce participant burden and improve completeness of follow-up. The opportunity highlights the need to ensure complete and accurate clinical data capture and biosample collection, with particular attention to measuring disease activity and clinically meaningful outcomes.

This is a cooperative agreement, meaning NIH will have substantial involvement in the conduct of the program compared to a standard research grant. The CureGN Data Coordinating Center (DCC) is funded under a separate notice of funding opportunity and is described as providing key leadership and coordination functions. In practice, the DCC role includes core responsibilities such as study organization, study design and implementation support, and biosample management. The PCCs funded under this opportunity would be expected to work closely within the CureGN network structure, aligning their operations, data and specimen workflows, and participant follow-up procedures with network-wide standards and DCC-led coordination.

Eligibility is broad across many U.S.-based organization types, reflecting typical NIH institutional eligibility rules and the collaborative nature of clinical research networks. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized governments; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education as applicable); for-profit organizations other than small businesses; and small businesses. The opportunity also explicitly mentions additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.

At the same time, there are important limits related to non-U.S. entities. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as applicants. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, which typically means a U.S. applicant organization may include certain defined project elements conducted outside the U.S. when appropriately justified and compliant with NIH policy.

From an administrative standpoint, the opportunity is categorized under health-related funding (CFDA/Assistance Listing 93.847) and uses the cooperative agreement mechanism to support networked research operations rather than a standalone project. The posted award ceiling is $500,000, and the original application due date listed is October 19, 2023. The overall intent is to maintain continuity of the CureGN cohort, strengthen long-term follow-up and retention, and modernize participation and data/biosample collection approaches through remote and virtual methods, all while operating in close coordination with the separately funded DCC that manages core network functions.

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Limited Competition for the Continuation of Cure Glomerulonephropathy (CureGN) Participating Clinical Centers (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
• This funding opportunity was created on 2023-07-14.
• Applicants must submit their applications by 2023-10-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $500,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA DK 22 512

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: