Opportunity Information: Apply for HT942526AZRPTRDA
The FY26 DoW Alzheimer's Transforming Diagnosis Award (TrDA) is a discretionary research grant offered through the Department of the Army (USAMRAA) under the Alzheimer’s Research Program (AZRP). It is designed to fund non-incremental, solutions-oriented projects that directly tackle major obstacles in the Alzheimer’s and related dementia space, specifically barriers that make it hard to achieve timely and accurate diagnosis, meaningful disease monitoring over time, and reliable prognosis. The emphasis is on work that can move the field forward in a practical way rather than incremental extensions of existing lines of study.
A key feature of this opportunity is that clinical research is permitted, but clinical trials are not allowed, and animal research is explicitly prohibited. In practical terms, applicants can propose human-focused studies and analyses, but they cannot run an interventional clinical trial as part of the award, and they cannot rely on animal models to generate or validate findings. Another important requirement is that preliminary data are required, signaling that the program expects applicants to show evidence of feasibility and a credible foundation for the proposed approach rather than purely speculative concepts.
For projects that will prospectively enroll human subjects, the program requires community collaboration. This typically means researchers need to involve community partners in a meaningful way, such as helping shape recruitment and engagement strategies, advising on participant-centered outcomes, supporting culturally competent procedures, or ensuring the work is aligned with community needs and realities. This requirement highlights that the program is not only concerned with scientific novelty, but also with real-world applicability and the ability to engage populations effectively and ethically.
On study populations and data sources, the AZRP encourages applicants to leverage existing cohorts and datasets whenever possible. This preference tends to favor proposals that can accelerate progress by using established longitudinal cohorts, registries, biobanks, health system data, or other curated data resources, rather than building everything from scratch. At the same time, the program explicitly encourages work involving cohorts of individuals age 65 or younger, reflecting interest in earlier-onset disease, early identification, and monitoring in younger populations where diagnostic pathways and prognostic tools may be less mature or less accessible.
The TrDA also includes a Career Initiation or Transition (CIT) Partnership Option that allows for more than one principal investigator and supports both new and existing collaborative partnerships. If a partnered application is recommended for funding, each PI is issued a separate award to their recipient organization, which can simplify multi-institution collaboration and clarify responsibility for each component of the work. When using this option, at least one independent investigator on the team must meet the CIT Partnership eligibility requirements at the time the application is submitted, making this mechanism particularly relevant for teams that include a newer independent investigator or someone transitioning into this research area who can benefit from structured collaboration.
Administratively, the funding opportunity is listed as HT942526AZRPTRDA, categorized as a grant in the science and technology/research and development area (CFDA 12.420). Eligibility is described as unrestricted, which generally indicates a broad range of applicant organizations may apply, subject to standard federal grant rules. The original closing date is September 24, 2026. The posting indicates an expectation of two awards, and an award ceiling is not stated in the provided summary, meaning applicants should consult the full announcement for budget limits, period of performance, and any cost restrictions.Apply for HT942526AZRPTRDA
- The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoW Alzheimer’s Transforming Diagnosis Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2026-05-01.
- Applicants must submit their applications by 2026-09-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted.
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FY26 DoW Alzheimer's Transforming Diagnosis Award (TrDA) FAQs
What is the FY26 DoW Alzheimer's Transforming Diagnosis Award (TrDA)?
The FY26 DoW Alzheimer's Transforming Diagnosis Award (TrDA) is a discretionary research grant offered through the Department of the Army (USAMRAA) under the Alzheimer's Research Program (AZRP). It supports research intended to transform how Alzheimer's disease and related dementias are diagnosed, monitored, and prognosticated.
Which agency and program are offering this opportunity?
This opportunity is offered through the Department of the Army (USAMRAA) under the Alzheimer's Research Program (AZRP).
What is the opportunity number?
The funding opportunity is listed as HT942526AZRPTRDA.
What CFDA number is associated with this grant?
The grant is listed under CFDA 12.420.
What type of projects is the TrDA designed to fund?
The TrDA is designed to fund non-incremental, solutions-oriented projects that directly address major obstacles that limit timely and accurate diagnosis, meaningful monitoring over time, and reliable prognosis in Alzheimer's disease and related dementias.
What does "non-incremental" mean in the context of this award?
Based on the description provided, "non-incremental" indicates the program is looking for work that moves the field forward in a practical way, rather than small extensions of existing research lines.
What scientific or clinical areas does the TrDA emphasize?
The emphasis is on overcoming barriers to (1) timely and accurate diagnosis, (2) meaningful disease monitoring over time, and (3) reliable prognosis for Alzheimer's disease and related dementias.
Is clinical research allowed under this award?
Yes. Clinical research is permitted.
Are clinical trials allowed under this award?
No. Clinical trials are not allowed under this award.
Is animal research allowed?
No. Animal research is explicitly prohibited.
Can an application include human-subjects research?
Yes. Applicants can propose human-focused studies and analyses, consistent with the statement that clinical research is permitted and that prospective enrollment of human subjects is contemplated (with additional requirements).
What is required if a project will prospectively enroll human subjects?
If a project will prospectively enroll human subjects, the program requires community collaboration. The description indicates community partners should be involved in a meaningful way, such as shaping recruitment and engagement strategies, advising on participant-centered outcomes, supporting culturally competent procedures, or aligning the work with community needs and realities.
What does "community collaboration" typically involve for this opportunity?
The provided description gives examples such as involving community partners to help shape recruitment and engagement strategies, advise on participant-centered outcomes, support culturally competent procedures, and help ensure the research is aligned with community needs and realities.
Are preliminary data required to apply?
Yes. Preliminary data are required, indicating that applicants are expected to provide evidence of feasibility and a credible foundation for the proposed approach.
Does the program encourage the use of existing cohorts or datasets?
Yes. AZRP encourages applicants to leverage existing cohorts and datasets whenever possible, such as established longitudinal cohorts, registries, biobanks, health system data, or other curated data resources.
Does the opportunity support building entirely new cohorts from scratch?
The summary indicates a preference for leveraging existing cohorts and datasets whenever possible. It does not state that new cohorts are prohibited, but it suggests proposals may be favored when they accelerate progress by using established resources.
Is there a specific interest in younger study populations?
Yes. The program explicitly encourages work involving cohorts of individuals age 65 or younger, reflecting interest in earlier-onset disease, early identification, and monitoring in younger populations.
What is the Career Initiation or Transition (CIT) Partnership Option?
The TrDA includes a Career Initiation or Transition (CIT) Partnership Option that allows for more than one principal investigator and supports new or existing collaborative partnerships.
Does the CIT Partnership Option allow multiple principal investigators (PIs)?
Yes. The CIT Partnership Option allows for more than one PI.
How are awards handled under the CIT Partnership Option if recommended for funding?
If a partnered application is recommended for funding, each PI is issued a separate award to their recipient organization, which can simplify multi-institution collaboration and clarify responsibility for each portion of the project.
Are there specific eligibility requirements to use the CIT Partnership Option?
Yes. When using the CIT Partnership Option, at least one independent investigator on the team must meet the CIT Partnership eligibility requirements at the time the application is submitted.
What does "eligibility is unrestricted" mean for this opportunity?
The summary states eligibility is "unrestricted," which generally indicates a broad range of applicant organizations may apply, subject to standard federal grant rules.
What is the application closing date?
The original closing date listed is September 24, 2026.
How many awards does the posting expect to make?
The posting indicates an expectation of two awards.
Is there an award ceiling (maximum budget) provided in the summary?
No. An award ceiling is not stated in the provided summary.
Where should applicants look for budget limits, period of performance, and cost restrictions?
Because the award ceiling is not included in the summary, applicants are expected to consult the full announcement for details such as budget limits, period of performance, and any cost restrictions.
What is the funding category or area for this grant?
The opportunity is categorized as a grant in the science and technology/research and development area.
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