Opportunity Information: Apply for RFA DP 19 003
The funding opportunity titled "Epidemiology of Lupus: Longitudinal Studies in Population-Based Cohorts" (RFA DP 19 003) is a CDC cooperative agreement designed to strengthen long-term, real-world epidemiologic data on lupus in the United States. It focuses on building and extending existing population-based infrastructure rather than starting from scratch, with an emphasis on tracking how lupus affects people over time and identifying modifiable factors that influence outcomes. The CDC frames this as a two-component program that collectively covers both adults and children with lupus, including systemic lupus erythematosus (SLE) and skin lupus, and it expects awardees to carry out structured longitudinal data collection over a multi-year period.
Component A supports a three-year longitudinal follow-up effort in an established, U.S.-based, population-based cohort of adults aged 18 and older who have diagnosed lupus. A key requirement is that the adult cohort must already exist and must have had follow-up data collected at least once since 2015, signaling that the CDC wants to invest in cohorts with demonstrated capacity to recontact participants and maintain continuity of data. The goal is to continue and expand data collection building on prior cohort development and initial follow-up activities, so investigators can better describe disease trajectories and evaluate how clinical care and social factors shape long-term outcomes in adult lupus populations.
For the adult cohort work, the NOFO specifies four core content areas that data collection should cover. The first is natural history, capturing how lupus evolves over time and what it means for severity, morbidity, mortality, disability, comorbidities, and functional impacts such as work interference. The second is treatment, including medications, therapies, and self-management strategies, with explicit attention to chronic pain management and opioid use, reflecting broader public health concerns around pain treatment and potential harms. The third area is health care access and gaps, aiming to document barriers to care, discontinuities, unmet needs, and other access-related problems that adults with lupus experience. The fourth area centers on disparities, including differences in outcomes by age, race/ethnicity, and sex, as well as other factors associated with lupus outcomes, which positions the work to inform equity-focused public health and health system interventions.
Component B funds a pediatric lupus registry with longitudinal follow-up, again emphasizing an existing, U.S.-based registry rather than creation of an entirely new one. The target population is children aged 0 to 17 years with diagnosed lupus (SLE and skin lupus). The project is expected to collect baseline data for the pediatric cohort and then continue follow-up for three additional years. In practice, this supports a more complete picture of pediatric lupus from an early point in the disease course and allows researchers to observe changes as children age, receive treatments, and interact with pediatric and potentially transitioning health care systems.
The pediatric registry and follow-up are expected to capture the same four content areas as the adult component, adapted to the pediatric context. Natural history includes monitoring severity, morbidity, mortality, disability, comorbidities, and life impacts, which for children can include school functioning and broader developmental considerations (even when not explicitly listed, these align with the work interference concept in age-appropriate form). Treatment data again encompasses medications, therapy, and self-management, including documentation related to chronic pain and opioid use where relevant. Health care access and gaps focus on the pediatric experience of obtaining specialty care, continuity of care, and barriers faced by children and their families. Disparities analysis similarly targets variation by age, race/ethnicity, and sex, along with other contributing factors that may shape pediatric lupus outcomes and long-term burden.
Administratively, this is a discretionary funding opportunity from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), using a cooperative agreement mechanism. That funding instrument signals that CDC expects substantial involvement, collaboration, or programmatic stewardship during the project period compared to a standard grant. The activity category is health, and the CFDA number listed is 93.283. The opportunity was posted January 4, 2019, with an original application due date of March 8, 2019 (applications due by 5:00 p.m. ET). The award ceiling is $1,000,000, and CDC anticipated making four awards.
Eligibility is broad and includes multiple types of public and private entities: state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) and small businesses; and other entities as allowed by the additional eligibility language. Overall, the NOFO is structured to accelerate high-quality, population-based longitudinal evidence on lupus outcomes, treatments, access to care, and inequities, with parallel investments in adult cohort follow-up and pediatric registry-based surveillance over a three-year follow-up horizon.Apply for RFA DP 19 003
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Epidemiology of Lupus: Longitudinal Studies in Population-Based Cohorts" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.283.
- This funding opportunity was created on Jan 04, 2019.
- Applicants must submit their applications by Mar 08, 2019 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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